Intrinsic bioconjugation for site-specific protein PEGylation at N-terminal serine.
نویسندگان
چکیده
Recently developed chemical ligation protocols were elaborated for rapid N-terminal protein PEGylation. We introduce a PEG-salicylaldehyde ester and demonstrate its site-specific ligation to the N-terminus of the RNase S protein and to the therapeutic polypeptide PTH (1-34).
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 52 شماره
صفحات -
تاریخ انتشار 2014